![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Natural plant-derived nanovesicles for effective psoriasis therapy via dual modulation of IL-17 and NRF2 pathway
Sreeram Peringattu, Kalarikkal and Meghana Kumar, N. and Soundaram, Rajendran and Jahnavi, Ravilla and Janakiraman, Narayanan and Gopinath Sundaram, M. and Cathrine, M. S. B. (2025) Natural plant-derived nanovesicles for effective psoriasis therapy via dual modulation of IL-17 and NRF2 pathway. Journal of iScience, 28. pp. 1-23.
![[img]](http://ir.cftri.res.in/style/images/fileicons/other.png) |
PDF
1-s2.0-S258900422500817X-main.pdf - Published Version Restricted to Registered users only Download (40MB) | Request a copy |
Abstract
Psoriasis is an inflammatory skin disease with aberrant epidermal differentiation and chronic inflammation. Plant-derived exosome-like nanovesicles (PDNVs) are exosome-mimetic structures isolated from plants with enhanced bioavailability and solubility. Herein, we investigated the therapeutic efficacy of PDNVs for psoriasis treatment. In our initial phenotype-driven screen, PDNVs from apple, garlic, and shallot displayed both pro-differentiation and anti-inflammatory activity in vitro. In imiquimod (IMQ)-induced psoriasis-like mu rine model, topical application of either shallot or garlic PDNV hydrogels led to complete recovery of normal skin phenotype. In porcine skin ex vivo assay, both shallot and garlic PDNVs displayed percutaneous pene tration up to the suprabasal epidermis. Using next generation sequencing and quantitative mRNA profiling in keratinocytes and murine skin, we elucidated a suppressive effect of shallot and garlic PDNVs on IL-17 signaling via modulation of upstream nuclear factor erythroid-2-related factor 2 (NRF2) pathway. Since PDNVs are economical to produce, shallot and garlic PDNVs could be natural and cost-effective topical alter native for psoriasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Natural plant, psoriasis therapy, NRF2 pathway |
| Subjects: | 500 Natural Sciences and Mathematics > 10 Plants 600 Technology > 01 Medical sciences > 09 Human Physiology |
| Divisions: | Molecular Nutrition |
| Depositing User: | Somashekar K S |
| Date Deposited: | 24 Jun 2025 08:15 |
| Last Modified: | 24 Jun 2025 08:15 |
| URI: | http://ir.cftri.res.in/id/eprint/19558 |
Actions (login required)
 |
View Item |