Dual-action of 2-Methyltetrahydrofuran-3-one (Coffee Furanone) as a natural fumigant and antimicrobial agent for stored grain protection

Shashideep, T. Suresh and Mokshith, D. Gajendra and Krishnaiah, H. Eraiah and Jinu, A. Varghese and Mamatha, S. Shivaramu and Keshava Murthy, Pavagada S. and Vivek Babu, Chikkarasanahalli S. and Rajashekar, Yallappa (2025) Dual-action of 2-Methyltetrahydrofuran-3-one (Coffee Furanone) as a natural fumigant and antimicrobial agent for stored grain protection. Food Bioscience, 74. pp. 1-10.

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Abstract

Stored grain pests and microbial contamination significantly impact global food security by contributing to post- harvest losses. This study investigates the dual-action efficacy of 2-methyltetrahydrofuran-3-one (coffee fur- anone) as a natural fumigant and antimicrobial agent. At 425 μg/L, it caused 87 % and 81 % mortality in Callosobruchus chinensis and Sitophilus oryzae, respectively, within 72 h, showing dose and species dependent responses. Coffee furanone also demonstrated potent antimicrobial activity against Escherichia coli, Salmonella enterica, Aspergillus niger, and Aspergillus flavus. Phytotoxicity tests confirmed its safety, with enhanced seed germination observed. Enzyme assays showed significant inhibition of acetylcholinesterase (AChE) and gluta- thione S-transferase (GST) in S. oryzae, while molecular docking revealed stable binding to AChE active sites. These findings suggest that coffee furanone is a promising, eco-friendly alternative to synthetic fumigants for integrated pest and microbial management in stored grains. Further studies are warranted to assess formulation stability and scalability for practical field applications.

Item Type:	Article
Uncontrolled Keywords:	2-Methyltetrahydrofuran-3-one, Natural fumigant, Anti-microbial agent, Enzyme inhibition, Molecular docking, Food security
Subjects:	600 Technology > 03 Agriculture > 05 Insect/Pest Control 600 Technology > 08 Food technology > 16 Nutritive value > 08 Grains
Divisions:	Food Packaging Technology Food Protectants and Infestation Control
Depositing User:	Somashekar K S
Date Deposited:	18 Dec 2025 11:20
Last Modified:	18 Dec 2025 11:20
URI:	http://ir.cftri.res.in/id/eprint/20208

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