Effect of oxidative stress on serum and antioxidant enzymes in liver and kidney of rats and their modulation through dietary factors.

Ramachandran, H. D. and Narasimhamurthy, K. and Raina, P. L. (2002) Effect of oxidative stress on serum and antioxidant enzymes in liver and kidney of rats and their modulation through dietary factors. Indian Journal of Experimental Biology, 40 (9). pp. 1010-10155. ISSN 0019-5189

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Abstract

Modulatory effect of a formulated diet based on cereals, pulses and spices incorporated with crude palm oil (CPO), soybean oil (SBO) or cod liver oil (CLO) at 10% dietary level on oxidative stress and antioxidant enzymes was studied in liver and kidney tissues. Activity of alkaline phosphatase (ALP) and acid phosphatase (ACP) increased significantly in serum in various experimental groups. Significant increase in hepatic antioxidant enzymes, catalase, glutathione peroxidase (GPx) was also seen in the experimental groups. SOD activity showed a mixed response. Further, kidney antioxidant enzymes did not show much change compared to those in liver. The results indicated dietary lipid as the key players in determining cellular susceptibility to oxidative stress, which could be modulated by cereals, pulses and spices in the diet.

Item Type:	Article
Uncontrolled Keywords:	Alkaline phosphatase; Acid phosphatase; Glutathione peroxidase
Subjects:	600 Technology > 08 Food technology > 11 Food Biochemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K.S
Date Deposited:	08 Jul 2011 09:04
Last Modified:	03 Oct 2018 09:39
URI:	http://ir.cftri.res.in/id/eprint/2079

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