Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.

Vishwanath, P. and Basappa, S. C. and Sreenivasamurthy, V. (1986) Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium. Folia Microbiologica, 31 (4). pp. 272-276.

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Abstract

Thymine and cytosine as well as the intermediates in pyrimidine biosynthetm pathway dihydroorotic acid, erotic acid, earbamyl aspartate and 5'-uridine monophosphato counteracted the toxic effect of aflatoxin in Bacillus megaterium. Folio acid and aminopterin counteracted the effect even better. The synergistic effect of thymine or 5'-uridlne monophosphate and relic acid, was synergistic. 2-14C-Thymine, 6-1aC-orotic acid and 14C-formate but not 2-14Curacil, were incorporated into DNA more in the presence of aflatoxin. These findings indicated that aflatoxin inhibited the pyrimidine base synthesis which could be overcome to a great extent by the addition of thymine and folic acid to aflatoxin-treated cells.

Item Type:	Article
Uncontrolled Keywords:	aflatoxin, Bacillus megaterium, Thymine, toxicity
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi 600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 08 Food technology > 10 Food Microorganisms
Divisions:	Food Microbiology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	16 Mar 2018 09:46
Last Modified:	16 Mar 2018 09:46
URI:	http://ir.cftri.res.in/id/eprint/2694

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