Biosynthesis of sulphated mucopolysaccharides in relation to vitamins A and K.

Perumal, A. S. and Swamy, T. S. A. and Lakshman, M. R. and Jungalwalla, F. B. and Rama Rao, P. B. (1966) Biosynthesis of sulphated mucopolysaccharides in relation to vitamins A and K. Biochemica Biophysica Acta, 124. pp. 95-100.

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Abstract

(I) Incorporation of NaiadS04 into acid mucopolysaccharides of intestine and colon tissue has been studied in normal, vitamin A-deficient and excess vitamin A-fed rats. (2) Vitamin A deficiency resulted in a significant decrease in [3~S]sulfate incorporation into mucopolysaccharides isolated from intestines of male rats. There was no significant change in the total mucopolysaccharides per gram of fresh tissue. (3) When rats are fed excessive amounts of retinyl acetate, increased [asSjsulfate incorporation into mucopolysaccharides of rat intestine and colon is observed. (4) Supplementation of vitamin K 1 to rats fed excessive amounts of vitamin A restores the incorporation of IsiS]sulfate into the acid mucopolysaccharides to the normal level. (5) The implications of these findings with special reference to the role of vitamins A and K in the synthesis of sulfated mucopolysaccharides are discussed.

Item Type:	Article
Uncontrolled Keywords:	mucopolysaccharides, vitamin deficiency, biosynthesis
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 04 Biosynthesis 600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 Mar 2018 07:09
Last Modified:	15 Mar 2018 07:09
URI:	http://ir.cftri.res.in/id/eprint/3197

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