Effect of vitamin B12 on the synthesis of protein and nucleic acids in the liver.

Sahasrabudhe, M. R. and Rao, M. V. L. (1951) Effect of vitamin B12 on the synthesis of protein and nucleic acids in the liver. Nature, 168. pp. 605-606.

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Abstract

IT is known that the cytoplasm content of the liver is determined by protein nutrition1, and recently vitamin B12 has been shown to promote amino-acid assimilation2. A decrease in liver basophile cells (attributable to ribonucleic acid) is observed in rats deficient in vitamin B123. The vitamin also protects against hepatic damage during carbon tetrachloride intoxication, which causes a considerable reduction in the ribonucleic acid content of the liver4. All these findings suggest that vitamin B12 may influence protein as well as nucleic acid metabolism in the liver. We have sought direct experimental evidence for this in studies based on the regeneration of the labile liver cytoplasmic proteins in the rat following a brief fast. The results of a typical experiment are presented here.

Item Type:	Article
Uncontrolled Keywords:	cytoplasm content, liver, vitamin B12, amino-acid assimilation
Subjects:	600 Technology > 01 Medical sciences > 12 Metabolism 600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	12 Apr 2013 06:49
Last Modified:	12 Apr 2013 06:49
URI:	http://ir.cftri.res.in/id/eprint/4063

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