Mammalian toxicity of technical x-factor. I. An acute oral study.

Krishnakumari, M. K. and Muralidhara, Dr. and Muralidhara, S. and Majumder, S. K. (1982) Mammalian toxicity of technical x-factor. I. An acute oral study. Journal of Environmental Science and Health, 17B. pp. 241-252.

PDF J. ENVIRON. SCI. HEALTH, B17(3), 241-252 (1982).pdf - Published Version Restricted to Registered users only Download (384kB) | Request a copy

Abstract

Intragastric administration of acute doses of Technical X-factor (ß-isomer free BHC, a byproduct obtained during separation of Lindane from Tech. BHC) carried in peanut oil elicited typical signs of central nervous system depression in adult rats. The computed oral LD5 0 values of X-factor were 4174 and 5673 mg/kg. body weight for male and female rats respectively indicating that its acute taxicity was of relatively low order compared to Tech. BHC. It is suggested that the low acute mammalian toxicity of X-factor could possibly be due to a direct antagonism of the delta isomer (present in larger proportion in X-factor) with the gamma isomer.

Item Type:	Article
Uncontrolled Keywords:	X-factor, Oral LD50, delta isomer, antagonism
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	07 Mar 2018 06:02
Last Modified:	07 Mar 2018 06:02
URI:	http://ir.cftri.res.in/id/eprint/4589

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