Single dose toxicity (oral) of a chronic anticoagulant rodenticide warfarin in albino rats.

Muktha Bai, K. and Krishnakumari, M. K. and Majumder, S. K. (1992) Single dose toxicity (oral) of a chronic anticoagulant rodenticide warfarin in albino rats. Comparative Physiology and Ecology, 17 (2). pp. 75-82.

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Abstract

Technical grade Warfarin (99.8%) carried in peanut oil was intragastrically adminiFtered to adult female albino rats (R. norvegicus). Out of five dosages, 1,2,4,8 and 12 mg/kg b. W., none of the rats succumbed to the first dosage, while other doses killed 25.0, 37.5,75.0 and 100% of the test rats respectively between 4-6 days. Those which did not succumb within thit p~riod, gJt over tf}! poisonin~ eff~ct gradualy and the LDso and LD90 values obtained w~re 5.6Z and 10, 11 mg/~g b.w. respectively. Among the survivors, histopathological examinations conducted at the end of 4th week revealed haemorrha~es'in orgaqs like liver, ki;i[u y. ovary, heart and adrenals but no significant changes wer~ cliscernlble in the relative organ weights except for lungs & ovary. The low L050 value and other r<lsults in1iclted that Warfarin apart from its chronic toxicity does possess the potential of a single dose toxicant against rodents. With a concentration of 0.05% in the bait and a restricted baiting period of 3-S days, the problem of tolerance/r~sistance of rodent population to warfarin could be overcome and thus warfarin could still be a useful and effective roden ticide in ,he years to come, if it is judiciously used.

Item Type:	Article
Uncontrolled Keywords:	Warfarin, rodenticide, single dose toxicant
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 03 Agriculture > 05 Insect/Pest Control
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	11 Mar 2013 06:26
Last Modified:	11 Mar 2013 06:26
URI:	http://ir.cftri.res.in/id/eprint/5362

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