Studies on the distribution of beta- and gamma-isomers of hexachlorocyclohexane in rat tissues.

Srinivasan, K. and Radhakrishnamurthy, R. (1983) Studies on the distribution of beta- and gamma-isomers of hexachlorocyclohexane in rat tissues. Journal of Environmental Science and Health, B18 (3). pp. 401-418.

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Abstract

A study of the comparitlve distribution pattern of β- and γ-isomers of hexachlorocyclohexane (HCH) in albino rat tissues as a function of duration of treatment at two dose levels revealed different accumulation patterns for the two isomers in tissues. In general, the accumulation pattern was found to be in the order: fat > kidney > lungs > liver > muscle > heart > spleen > brain > blood for β-HCH and fat > brain > kidney > muscle > lungs > heart > spleen > liver > blood for γ-HCH. The tissue accumulation of β-isomer was always greater than that of γ-isomer in any tissue except in brain. Brain β-HCH residue levels were relatively lower than in many other tissues except blood, whereas brain γ-HCH concentration was only next to fat. A higher dose or a longer period of treatment generally produced a more marked elevation of tissue residue levels in β-HCH fed rats, but not in γ-HCH treated animals.

Item Type:	Article
Uncontrolled Keywords:	hexachlorocyclohexane, distribution, food restriction, gas-liquid chromatography
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	28 Mar 2018 05:26
Last Modified:	28 Mar 2018 05:26
URI:	http://ir.cftri.res.in/id/eprint/5731

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