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Differential effects of dietary lipids and curcumin on kidney microsomal fatty acids and Na+,K+-ATPase activity in rat.
Joe, B and Prasad, S. R. and Sambaiah, K. and Krishnakantha, T. P. and Lokesh, B. R. (1992) Differential effects of dietary lipids and curcumin on kidney microsomal fatty acids and Na+,K+-ATPase activity in rat. Nutrition Research, 12 (7). pp. 893-904.
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Abstract
The effect of dietary lipids and the spice curcumin on kidney microsomal lipids, Na+,K+-ATPase activity and serum lipid values were studied. Male Wistar rats were fed on a diet containing coconut, safflower or menhaden oil for 8 weeks. Safflower oil and menhaden oil feeding resulted in the accumulation of n-6 polyunsaturated fatty acids (PUFA) and n-3 PUFA, respectively in the kidney microsomes. The specific activity of Na+,K+-ATPase was higher by 26% in rats fed on safflower oil compared with rats fed on coconut or menhaden oil. Supplementation of curcumin in the diets containing different lipids did not effect kidney microsomal fatty acid profiles or Na+,K+-ATPase activity. However, dietary curcumin reduced serum triacylglycerol value by 44% in safflower oil-fed rats and serum cholesterol values by 24 and 31% in rats fed on safflower and menhaden oil, respectively. It is indicated that dietary lipids and curcumin differentially affect membrane fatty acid composition, Na+,K+-ATPase activity and serum lipids.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | coconut-oil; menhaden-oil; safflower-oil; spices-; fatty-acids; composition-; microsomes-; kidneys-; fats-; sources-; curcumin-; intake-; adenosinetriphosphatase-; activity-; membranes-; blood-lipids |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 22 Lipid Chemistry 600 Technology > 01 Medical sciences > 13 Nutrition-Human |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 15 Jun 2011 06:54 |
| Last Modified: | 01 Oct 2018 09:28 |
| URI: | http://ir.cftri.res.in/id/eprint/6537 |
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