Metabolism and embryotoxicity of heptachlor in the albino rat (Rattus norvegicus).

Rani, B. E. A. and Krishnakumari, M. K. and Karanth, N. G. K. (1993) Metabolism and embryotoxicity of heptachlor in the albino rat (Rattus norvegicus). Journal of Environmental Biology, 14 (1). pp. 77-87.

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Abstract

Heptachlor fed to female rats at 120 mg/kg b.w. was metabolized in the body. The parent molecule and its 4 metabolites were detected in different tissues. GC and TLC analyses showed higher levels of toxic epoxide in the reproductive organs, and the concn increased during pregnancy. Conversely, concn of the less toxic hydroxy metabolites were low and decreased during pregnancy, indicating slow metabolic handling of heptachlor and heptachlor epoxide. This could lead to the build up of these 2 compounds, causing toxicity to the embryos by altered steroidogenesis, essential for term pregnancy.

Item Type:	Article
Uncontrolled Keywords:	toxicity-; nontarget-effects; heptachlor-; effects-; insecticides-; pesticides-; agricultural-entomology
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	04 Jan 2017 12:14
Last Modified:	04 Jan 2017 12:14
URI:	http://ir.cftri.res.in/id/eprint/8343

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