Effect of alpha-naphthylthiourea on (Na+ + K+)-ATPases in albino rats.

Patil, T. N. and Radhakrishnamurty, R. (1978) Effect of alpha-naphthylthiourea on (Na+ + K+)-ATPases in albino rats. Indian Journal of Biochemistry and Biophysics, 15 (4). 294-298; 29 ref..

PDF Indian Journal of Biochemistry and Biophysics, Volume-15( (1978) 294-298.pdf - Published Version Restricted to Registered users only Download (157kB)

Abstract

PESTAB. A study was undertaken to determine the effects of alpha-naphthylthiourea (ANTU), a specific acute rodenticide, on ATPases in different tissues. Female Wistar rats were given oral doses of ANTU (10 mg/kg). Erythrocyte membrane, liver microsomes, and kidney microsomes were assayed for (Na+ + K+)-ATPases. Inhibition of (Na+ + K+)-ATPases occurred in erythrocyte membranes and kidney microsomes. There were no effects observed with ATPases activated by 2,4-dinitrophenol, magnesium or calcium from liver and kidney mitochondria. There was substantial reversal of inhibition by phosphatidyl choline, phosphatidyl ethanolamine, and adenosine triphosphate.

Item Type:	Article
Uncontrolled Keywords:	alpha-naphthylthiourea atpases rodenticide
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	28 Dec 2016 05:54
Last Modified:	28 Dec 2016 05:54
URI:	http://ir.cftri.res.in/id/eprint/8627

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