Hypolipidemic effect of oryzanol concentrate and low temperature extracted crude rice bran oil in experimental male wistar rats.

Blends of refined groundnut oil (GNO) and oryzanol
concentrate having 3, 5, and 10% oryzanol in the
blend, and a rice bran oil (RBO) which had retained all the
nutrients such as oryzanol, tocopherols and tocotrienols and
the unsaponifiable matter components of crude oil (GWF
RBO) were prepared. Weanling rats were fed with diet
containing the oil blends/rice bran oil at 10% level for
60 days and then dissected. The lipid profiles in serum, liver
were investigated and the cholesterol levels were marginally
reduced (7–16% in serum, 10–14.5% in liver) in rats fed
oryzanol containing diet. RBO, GWF RBO containing diets
showed a reduction of serum cholesterol by 14%, 15%
respectively when compared to those fed with GNO. Serum
and liver lipid analysis also showed significant change in
TG concentration in rats fed blended oils containing oryzanol
compared to the rats given GNO. Histology of liver and
kidneys did not show changes. These studies indicated that
oryzanol has an effect in lowering serum and liver cholesterol
and shows antiatherogenic properties when incorporated into
groundnut oil.