Responses to phosphate deprivation in yeast cells

Kamlesh Kumar, Yadav and Neelima, Singh and Ram, Rajasekharan (2016) Responses to phosphate deprivation in yeast cells. Current Genetics, 62. pp. 301-307.

PDF Curr Genet (2016) 62301–307.pdf - Published Version Restricted to Registered users only Download (969kB)

Abstract

Inorganic phosphate is an essential nutrient because it is required for the biosynthesis of nucleotides, phospholipids and metabolites in energy metabolism. During phosphate starvation, phosphatases play a major role in phosphate acquisition by hydrolyzing phosphorylated macromolecules. In Saccharomyces cerevisiae, PHM8 (YER037W), a lysophosphatidic acid phosphatase, plays an important role in phosphate acquisition by hydrolyzing lysophosphatidic acid and nucleotide monophosphate that results in accumulation of triacylglycerol and nucleotides under phosphate limiting conditions. Under phosphate limiting conditions, it is transcriptionally regulated by Pho4p, a phosphate-responsive transcription factor. In this review, we focus on triacylglycerol metabolism in transcription factors deletion mutants involved in phosphate metabolism and propose a link between phosphate and triacylglycerol metabolism. Deletion of these transcription factors results in an increase in triacylglycerol level. Based on these observations, we suggest that PHM8 is responsible for the increase in triacylglycerol in phosphate metabolising gene deletion mutants.

Item Type:	Article
Uncontrolled Keywords:	Stress · Low phosphate · Lysophosphatidic acid phosphatase · Triacylglycerol · Monoacylglycerol · Metabolic pathway · Transcription factor
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 16 Enzyme Chemistry 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 19 Yeast
Divisions:	Lipid Science and Traditional Foods
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	10 Aug 2016 12:16
Last Modified:	10 Aug 2016 12:16
URI:	http://ir.cftri.res.in/id/eprint/12245

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