Screening of Anti-Inflammatory and Anti-Platelet Aggregation Property Studies from Ipomea staphylina

Priyadarshini, K. and Akhilender Naidu, K. and Raghavendra, R. H. (2013) Screening of Anti-Inflammatory and Anti-Platelet Aggregation Property Studies from Ipomea staphylina. Open Access Scientific Reports, 2 (4). pp. 1-4.

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Abstract

Inflammation is a biological reaction which is a part of non-specific immune response that occurs in a series of reaction to any type of injury, damage caused to the body. Although there has been enough progress in the usage of colossal improved anti-inflammatory drugs, they are known to make up just around half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which might affect the central nervous system. Thus researches in screening up of anti-inflammatory components from the plants have been shown very good progress. Such similar property was been screened using Ipomea staphylina, a local weed belonging to Convulvulaceae family. Study included the mechanism by which the Convulvulaceae species I. staphylina inhibited inflammatory pathway key enzymes. Plant extract was randomly divided into 3 groups namely water extract, ethanol extract and methanol extract. We screened by randomized trials to estimate levels of all the three key enzymes activity involved in inflammation i.e., PLA2, COX (cyclooxygenase) & LOX (lipoxygenase) using the plant sample. Results show that the water extract of the Plant sample inhibited secretory PLA2 significantly than the other groups. PLA2 was significantly inhibited as the concentration of the sample increased and this showed reproducible results. COX and LOX had inhibitory effects but not to a greater extent. These data suggest that the crude plant water extract had molecules that inhibited PLA2 which is the first enzyme in the inflammatory pathway.

Item Type:	Article
Uncontrolled Keywords:	Anti-inflammatory; Anti platelet aggregation; Ipomea staphylina; Phospholipase A2; Plant aqueous extract; COX; LOX
Subjects:	500 Natural Sciences and Mathematics > 10 Plants 600 Technology > 01 Medical sciences > 15 Pharmacology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	26 Sep 2016 06:13
Last Modified:	10 Oct 2018 10:55
URI:	http://ir.cftri.res.in/id/eprint/12336

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