Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats.

The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum
lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented
with 10 wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats
given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver,
and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils. The rats fed with native oils of RBO and
SESO showed an upregulation of sterol regulatory element-binding protein (SREBP)-2 and peroxisome proliferator-activated
receptor gamma (PPARc) and downregulation of nuclear factor-kappa B (NF-jB) p65. These effects of native oil were
significantly compromised when rats were given MCR oils. In conclusion, the minor constituents significantly support the
hypolipidemic and anti-inflammatory properties of RBO and SESO.