Solid Lipid Nanoparticle enhances bioavailability of Hydroxycitric acid than microparticle delivery system.

Ezhilarasi, P. N. and Muthukumar, S. P. and Anandharamakrishnan, C. (2016) Solid Lipid Nanoparticle enhances bioavailability of Hydroxycitric acid than microparticle delivery system. RSC Advances, 6. pp. 53784-53793.

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Abstract

Solid lipid nanoparticles (SLN) are most promising delivery system that improves the stability, bioavailability and controlled release of food bioactive compounds. The delivery of any bioactive compound to targeted sites is directly affected by particle size and thus nano delivery system has the potential to enhance bioavailability, controlled release of the bioactive compounds in a greater extent than microencapsulation. However, the effect of different particle size on the bioavailability of the active compound was less explored. Moreover, nanoencapsulation of hydrophilic compound by SLN technique was not much studied due to the complexity involved in non-compatibility between the hydrophilic core and lipophilic wall matrix. Hence, in order to improve efficiency of SLN to load the hydrophilic molecules and to evaluate the effect of micro and nanoparticles on the bioavailability, HCA, a model hydrophilic compound was nanoencapsulated using solid lipid nanocarriers. The HCA loaded SLN (327 nm) exhibited encapsulation efficiency of about 57 % and excellent storage stability with retention of 82 % HCA and 558 nm particle size during 50 days of storage. Moreover, in simulated gastrointestinal conditions, SLN-HCA exhibited higher gastrointestinal stability (about 88%) of HCA with better retention of particle size and also shown excellent controlled release of HCA. On comparison of bioavailability , HCA loaded nanoparticles (SLN-HCA) had 2 fold higher bioavailability than unencapsulated HCA and 1.3 fold higher bioavailability than the microparticles (SLM-HCA) due to smaller particle size, longer residence time and controlled release of HCA..

Item Type:	Article
Uncontrolled Keywords:	Nanotechnology, bioactive compounds, delivery system
Subjects:	600 Technology > 08 Food technology > 07 Food Engineering
Divisions:	Food Engineering
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	22 Jan 2018 05:18
Last Modified:	22 Jan 2018 05:18
URI:	http://ir.cftri.res.in/id/eprint/13354

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