Jagannatha Rao, K. S. and Ramesh, J. and Easwaran, K. R. (1999) Neuropeptide Y structure is modulated by aluminium in the hypothalamus. Alzheimer's Reports, 2 (2). pp. 99-103.
![[thumbnail of Alz Report 2(2) 1999 99-103.pdf]](http://ir.cftri.res.in/style/images/fileicons/other.png "Alz Report 2(2) 1999 99-103.pdf")
PDF
Alz Report 2(2) 1999 99-103.pdf - Published Version
Restricted to Registered users only
Download (172kB) | Request a copy
Abstract
Aluminium is an element suspected to contribute to the pathogenesis of Alzheimer's dise<.lse, but its
mechanism of action is not clear. Neuropeptide Y (NPY) plays a significant role in feeding behaviour.
Our spectroscopic, ELISA, and western blot studies indicate that aluminium interacts with neuropeptide
Y and alters significantly the a-helical content. We found that aluminium reduced levels of NPY in the
hypothalamus of aged rabbits. NPY polyclonal antibody interaction was found to depend upon the ahelical
content of NPY. These results clearly show that aluminium alters NPY structure and this could
explain the abnormality in feeding behaviour seen in patients with Alzheimer's disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alzheimer's disease, Neuropeptide Y, Aluminium |
| Subjects: | 600 Technology > 01 Medical sciences > 02 Anatomy |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 14 Feb 2018 11:01 |
| Last Modified: | 14 Feb 2018 11:01 |
| URI: | http://ir.cftri.res.in/id/eprint/13417 |
Actions (login required)
- View Item