Ameliorative effect of flaxseed (Linum usitatissimum) and its protein on ethanol‐induced hepatotoxicity in Wistar rats.

Salma, Nida Ume and Muthukumar, S. P. and Jyothi Lakshmi, A. (2020) Ameliorative effect of flaxseed (Linum usitatissimum) and its protein on ethanol‐induced hepatotoxicity in Wistar rats. Journal of Food Biochemistry. ISSN 1745-4514

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Abstract

Hepatoprotective effect of flaxseed and its protein on ethanol‐induced hepatotoxic‐ ity in adult Wistar rats was investigated. The rats were divided into eight groups of which two served as control (group I: Control for AIN‐93M diet groups and group II: Control for cereal‐pulse diet groups) and six groups received ethanol orally every day. After 10 days along with ethanol, the rats received AIN‐93M diet (group III); AIN‐93M diet and commercial hepatoprotective formulation (CHF) (group IV); casein replaced by flaxseed protein in AIN‐93M diet (group V); cereal‐pulse diet (group VI); cereal‐pulse diet and CHF (group VII); cereal‐pulse diet containing flaxseed (group VIII) for four weeks. The flaxseed and its protein significantly prevented the eleva‐ tion of plasma markers of hepatic damage, lowered lipid peroxidation, mitigated changes in antioxidant enzymes, and suppressed histopathological signs of hepatic damage. The hepatoprotective effect of flaxseed and its protein was comparable to CHF. These findings implicate the ameliorative effect of flaxseed and its protein on ethanol‐induced hepatotoxicity. Practical applications Owing to globalization and an increase in earning capacity, alcohol consumption is becoming a part of social life and gradually transforming to addiction. Binge drinking is highly prevalent among low socioeconomic status population, which poses severe risks to health. Alcohol abuse is a public health problem causing three million deaths annually worldwide. Alcohol consumption is known to be a major cause of liver dam‐ age worldwide and has contributed to 44% of deaths from liver disease. As abstaining from alcohol is a challenging task, there is an escalating need to formulate potential hepatoprotective agents to prevent alcohol‐induced hepatic damage. This study in‐ vestigates the efficacy of flaxseed and its protein in conferring protection to the liver against ethanol‐induced hepatotoxicity. This study also explores the benefits of incorporating flaxseed in the staple cereal‐pulse diet. Findings of this study suggest that incorporation of flaxseed or its protein in food formulations can prevent hepato‐ toxicity and improve the overall quality of life among alcoholics.

Item Type:	Article
Uncontrolled Keywords:	bilirubin, ethanol‐induced hepatotoxicity, flaxseed, malondialdehyde, protein concentrate
Subjects:	600 Technology > 08 Food technology > 16 Nutritive value > 03 Proteins 600 Technology > 08 Food technology > 19 Lipids-oils/fats > 01 Oilseeds
Divisions:	Dept. of Biochemistry Protein Chemistry and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	01 Oct 2020 05:03
Last Modified:	01 Oct 2020 05:03
URI:	http://ir.cftri.res.in/id/eprint/14484

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