Bioengineering of Microalgae: Recent Advances, Perspectives, and Regulatory Challenges for Industrial Application.

Gulshan, Kumar and Ajam, Shekh and Sunain, Jakhu and Yogesh, Sharma (2020) Bioengineering of Microalgae: Recent Advances, Perspectives, and Regulatory Challenges for Industrial Application. Frontiers in Bioengineering and Biotechnology, 8. p. 914.

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Abstract

Microalgae, due to their complex metabolic capacity, are being continuously explored for nutraceuticals, pharmaceuticals, and other industrially important bioactives. However, suboptimal yield and productivity of the bioactive of interest in local and robust wild-type strains are of perennial concerns for their industrial applications. To overcome such limitations, strain improvement through genetic engineering could play a decisive role. Though the advanced tools for genetic engineering have emerged at a greater pace, they still remain underused for microalgae as compared to other microorganisms. Pertaining to this, we reviewed the progress made so far in the development of molecular tools and techniques, and their deployment for microalgae strain improvement through genetic engineering. The recent availability of genome sequences and other omics datasets form diverse microalgae species have remarkable potential to guide strategic momentum in microalgae strain improvement program. This review focuses on the recent and significant improvements in the omics resources, mutant libraries, and high throughput screening methodologies helpful to augment research in the model and non-model microalgae. Authors have also summarized the case studies on genetically engineered microalgae and highlight the opportunities and challenges that are emerging from the current progress in the application of genome-editing to facilitate microalgal strain improvement. Toward the end, the regulatory and biosafety issues in the use of genetically engineered microalgae in commercial applications are described.

Item Type:	Article
Uncontrolled Keywords:	microalgae, genetic engineering, omics, genome editing, regulatory issues
Subjects:	500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 01 Algae 600 Technology > 05 Chemical engineering > 01 Biotechnology and Bioengineering
Divisions:	Plant Cell Biotechnology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	27 Nov 2020 06:54
Last Modified:	27 Nov 2020 06:54
URI:	http://ir.cftri.res.in/id/eprint/14655

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