Role of n-3 Fatty Acids on Bile Acid Metabolism and Transport in Dyslipidemia: A Review.

Pooja, Acharya and Vinayak, Uppin and Mehrdad, Zarei and Ramaprasad, T. R. (2020) Role of n-3 Fatty Acids on Bile Acid Metabolism and Transport in Dyslipidemia: A Review. Lipids. ISSN 0024-4201

PDF Lipids (2020).pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy

Abstract

Dietary n-3 fatty acids, especially of marine origin, eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3), have always been lauded for their profound effects on regulating the risk factors for major metabolic disorders. Yet, their consumption rate is poor compared to n-6 fatty acids [linoleic acid (18:2n-6)], which are predominantly consumed. Hence, the skewed n-6 to n-3 fatty acid ratio may have a bearing on the risk factors of various diseases, including dyslipidemia. Dyslipidemia and other lifestyle diseases associated with it, such as diabetes, obesity, hypertension, are a growing concern in both developed and developing countries. A common strategy for addressing dyslipidemia involves bile acid (BA) sequestration, to interrupt the enterohepatic circulation of BA, resulting in the modulation of lipid absorption in the intestine, thereby normalizing the levels of circulating lipids. The BA homeostasis is under the tight control of hepatic and enteric BA transporters. Many investigations have reported the effects of dietary constituents, including certain fatty acids on the reabsorption and transport of BA. However, a critical review of the effects of n-3 fatty acids on BA metabolism and transport is not available. The present review attempts to explore certain unmapped facets of the n-3 fatty acids on BA metabolism and transport in dyslipidemia, and their interplay with biological processes involving lipid rafts and gut microbiome.

Item Type:	Article
Uncontrolled Keywords:	Bioactive lipids Cholesterol Enterohepatic circulation Metabolic syndrome n-3 fatty acids Polyunsaturated fatty acids
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 07 Metabolism
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	21 Feb 2022 04:33
Last Modified:	21 Feb 2022 04:33
URI:	http://ir.cftri.res.in/id/eprint/15126

Actions (login required)

View Item