Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells.

The molecular pathophysiology of cardiometabolic diseases is known to be influenced by
dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may
be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian
medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS)
production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 �M
oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was
significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii.
Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the
production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura
tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion.
In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica
reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These
findings highlight some interesting properties of these Cameroonian spice extracts in the modulation
of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming
to develop novel treatment options for these conditions based on nutraceutical products.