Neuroprotective, lifespan, memory enhancing potential, and molecular docking studies of natural compound from Curculigo orchioides Gaertn.,: A study on Alzheimer’s disease model of Appl-GAL4 Drosophila melanogaster.

Alzheimer’s (AD) is one of the most common age-related neurodegenerative diseases in the world. Currently
it has affected about 33.9 million people and is estimated to triple over the next 5 years. The accumulation of
amyloid-beta plaques in the neurons is one of the important characteristic features of AD which leads to the
gradual decline of a person’s memory, learning and reasoning ability leading to difficulty in carrying out daily
activities. Medicinal plants are the main ingredients of native medicines and have a major role in traditional
health care. Of late, medicinal plants are being accepted widely because of fewer side effects compared to
synthetic drugs. Moreover, they also meet the requirement of medicine necessary for increasing human pop�ulation. Medicinal plants play a crucial role in the development of new herbal drugs. Curculigo orchioides
Gaertn., commonly known as Kali Musli or golden grass, is extensively utilised as a nutritive tonic for
strength and treatment of asthma, skin diseases, neurodegenerative diseases, diarrhea, etc. To isolate and
characterize the MS-1 compound from Curculigo orchioides Gaertn.,rhizome. The isolated compound was
analysed by LC-MS, HPLC, FTIR, and 13 C &1 H��NMR and molecular docking studies. The neuroprotective
effect of the MS-1compound was evaluated on the Appl-GAL4 model of D.melanogaster. The MS-1compound
showed good neuroprotection, antioxidant activity and also increased the climbing activity and the lifespan
of Drosophila. These results might explain the effect of MS-1 compound as a good neuroprotective agent. In
the future, it can be used in making anti-Alzheimer drugs