Anti-inflammatory effect of resin fraction of cardamom (Elettaria cardamomum) in carrageenan-induced rat paw edema

Shantaram, Arpitha and Krishnapura, Srinivasan and Halagur Sowbhagya, B. (2019) Anti-inflammatory effect of resin fraction of cardamom (Elettaria cardamomum) in carrageenan-induced rat paw edema. PharmaNutrition, 10. pp. 1-6.

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Abstract

Volatile and non-volatile fractions of cardamom (Elettaria cardamomum) seeds were evaluated for anti-in- flammatory influence in paw edema-induced Wistar rats. Groups of rats were orally administered with car- damom oil, cardamom resin, and standard compounds of the volatile cardamom oil fraction as a single dose. Paw inflammation was measured at hourly intervals for 6 h post-carrageenan administration (i.p.). In another set, groups of rats were maintained for 10 days on diets containing cardamom oil and cardamom resin, and paw edema was induced at the end. Among the cardamom fractions administered orally, aqueous and acetone ex- tracts showed a higher degree of inhibition (31 and 30%) compared to ibuprofen (23%). Cardamom oil exhibited 11% inhibition in the first hour, while 1,8-cineole produced 9.5% inhibition in the second hour. In the dietary study, de-oiled cardamom powder showed 9% inhibition at the first hour, while cardamom powder and car- damom oil were not effective in inhibiting the inflammation. De-oiled cardamom powder (obtained by acetone extraction) was effective indicating that non-volatile compounds present in this resin fraction are responsible for the anti-inflammatory effect. Thus, the components of the non-volatile (resin) portion of cardamom viz., poly- phenols, fatty acids, and sterols are responsible for the anti-inflammatory potential of cardamom seeds.

Item Type:	Article
Uncontrolled Keywords:	Cardamom seeds, Elettaria cardamomum, Volatile oil, resin fractions, Anti-inflammatory effect, Carrageenan-induced paw edema
Subjects:	600 Technology > 01 Medical sciences > 01 Allergy 600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Plantation Products Spices and Flavour Technology Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	11 Mar 2025 08:57
Last Modified:	11 Mar 2025 08:57
URI:	http://ir.cftri.res.in/id/eprint/19277

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