Effect of aluminium (Al) on brain mitochondrial monoamine oxidase-A (MAO-A) activity--an in vitro kinetic study.

Rao, K. S. J. and Rao, G. V. (1994) Effect of aluminium (Al) on brain mitochondrial monoamine oxidase-A (MAO-A) activity--an in vitro kinetic study. Molecular and Cellular Biochemistry, 137 (1). pp. 57-60. ISSN 0300-8177

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Abstract

Effect of aluminium (Al) on rat brain mitochondrial monoamine oxidase-A (MAO-A) was studied in vitro at three different pH (4.0, 7.4 and 9.0) values. The results have shown that Al is a non-competitive inhibitor for MAO-A. The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions. Al altered the maximum velocity (Vmax) of MAO-A but did not affect substrate-enzyme affinity (Km). Al formed a strong chelation with the substrate (Kynuramine) (1:1).

Item Type:	Article
Uncontrolled Keywords:	aluminium, monoamine oxidase, kynuramine
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	21 Mar 2018 09:14
Last Modified:	21 Mar 2018 09:14
URI:	http://ir.cftri.res.in/id/eprint/2268

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