Naidu, K. A. (1989) Inhibition of monoamine oxidase by the fungicide metalaxyl. Journal of Toxicology and Environmental Health, 27 (3). pp. 395-8. ISSN 0098-4108
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Abstract
The in vitro effect of metalaxyl on monoamine oxidase (MAO) activity in rat heart was studied. Metalaxyl decreased MAO activity in a dose-dependent manner. The inhibitory concentration (IC50) for metalaxyl was found to be 19 mumol. Substrate-dependent kinetic studies demonstrated noncompetitive inhibition as evidenced by decreased velocity of enzyme activity (Vmax) without significant change in enzyme-substrate affinity (Km). The inhibition of MAO activity by metalaxyl suggests interference with amine metabolism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | metalaxyl, monoamine oxidase, fungicide |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 01 Medical sciences > 17 Toxicology |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 20 Mar 2018 08:09 |
| Last Modified: | 20 Mar 2018 08:09 |
| URI: | http://ir.cftri.res.in/id/eprint/2360 |
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