Comparative toxicities of shoxin to different test animals.

Recently a specific carboximide tmder the trade name Shoxin has been
synthesized in U.S.A. and claimed to be toxic only to lWltus rattus. Acute toxicity
experiment, of the chemical 'ShQxin' (5-(a-hydroyey-a-Z-pyridylbenzyl)-7a-
Z-pyridylbenzylidene-5-norbomene-Z-, 3.dicarboximide), to various animal
species were conducted. This chemical did nOi have any effect on the animals
like Indian gerbil, guineapigs, rahbits, pigeons and cockerels when fed at 600
mg.{kg. body weight and invertebrates like earthworms and insects. During
the experimental period of fifteen days all the animals were normal and did not
show any toxic symptom. Shoxin killed Rauu> raltus within two hours at 64mg./
kg. body weight. Albino rats (R. Iwrvegicus) were more susceptible than
Rallus raltus and some albino rats died instantaneously at 6 mg,/kg. body weight
level. Some anticoagulant and vasodilator dnlgs when tested did no t alter
the toxicity of Shoxin.