Effect of low dietary protein on the mammalian toxicity of technical X-factor.

Muralidhara, S. and Krishnakumari, M. K. and Majumder, S. K. (1986) Effect of low dietary protein on the mammalian toxicity of technical X-factor. Journal of Food Science and Technology , 23 (5). pp. 281-286.

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Abstract

For 6 weeks groups of 36 female rats weighing 40 to 45 g were given diets with 7 (LP) and 17% (NP) protein. After 6 weeks, mean body weight for NP and LP rats was 133 and 80 g. Technical X-factor (a byproduct obtained during separation of lindane from technical benzene hexachloride) was given by stomach tube to rats given NP diet at 2, 3, 4 and 6.75 g/kg body weight and to rats given LP diet at 0.4, 0.6, 0.89 and 1.33 g/kg body weight. For rats given NP and LP diets LD50 of technical X-factor was 5.111 and 0.784 g/kg body weight, respectively. In a further trial male rats had free access for 90 days to LP or NP diets containing technical X-factor 25 or 1500 mug/g. Only rats given LP diet developed signs of X-factor poisoning and with X-factor 1500 mug/g mortality rate was 33.3%. Rats given LP diet and X-factor 1500 mug/g showed more hyptrophy of liver and testis than did those given other treatments. Activities of serum and liver transaminases and glucose-6-phosphatase in rats given LP and NP diets with X-factor 1500 mug/g were significantly different from control values.

Item Type:	Article
Uncontrolled Keywords:	Protein-deficiencies; pesticides-; toxicity-
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	11 Mar 2009 09:23
Last Modified:	14 Dec 2016 11:40
URI:	http://ir.cftri.res.in/id/eprint/8538

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