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Immunomodulatory effects of protein hydrolysates from rohu (Labeo rohita) egg (roe) in BALB/c mice.
Chalamaiah, M. and Hemalatha, R. and Jyothirmayi, T. (2014) Immunomodulatory effects of protein hydrolysates from rohu (Labeo rohita) egg (roe) in BALB/c mice. Food Research International, 62. pp. 1054-1061.
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Food Research International, Volume 62, August 2014, Pages 1054-1061.pdf - Published Version Restricted to Registered users only Download (735kB) |
Abstract
Protein hydrolysates prepared from underutilized rohu (Labeo rohita) egg (roe), by enzymatic hydrolysis using pepsin, trypsin and Alcalase, were evaluated for their immunomodulatory effects in BALB/c mice. The female BALB/c mice (4–6 weeks, 18–20 g) were administered with the rohu egg protein hydrolysates (REPHs) daily for a period of forty five days with concentration of 0.25, 0.5 and 1 g/kg body weight. Both innate and adaptive immune responses were studied. Pepsin hydrolysate significantly increased the splenic NK cell cytotoxicity, macrophage phagocytosis and level of serum immunoglobulin A (IgA). The mucosal immunity (S-IgA) in the gutwas significantly enhanced by pepsin and Alcalase hydrolysates.Whereas trypsin hydrolysate induced significant increases in the percentages of CD4+ and CD8+ cells inthe spleen. This study confirms that REPHs are able to modulate immune function and further reveals that different rohu egg protein hydrolysates may exert differential influences on the immune system. These results suggest that REPHs contain immunostimulatory peptides that could be useful in pharmaceutical, health food or nutraceutical industry for various applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Labeo rohita fish egg (roe), Enzymatic hydrolysis Protein hydrolysates, Bioactive peptides Immunomodulatory activity |
| Subjects: | 600 Technology > 08 Food technology > 16 Nutritive value > 03 Proteins 600 Technology > 08 Food technology > 28 Meat, Fish & Poultry > Fish |
| Divisions: | CFTRI Resource Centres > Hyderabad |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 08 Jul 2014 05:45 |
| Last Modified: | 08 Jul 2014 05:45 |
| URI: | http://ir.cftri.res.in/id/eprint/11612 |
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