Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy.

Hegde, V. L. and Mahesh, P. A. and Venkatesh, Y. P. (2018) Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy. European Annals of Allergy and Clinical Immunology, 50 (1). pp. 10-18.

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Abstract

The association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa). We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin. Among patients with a history of food allergy to tomato fruit, the association was more pronounced (66%). Tomato profilin appears to be an important cross-sensitizing panallergen in respiratory allergic patients in the Indian subcontinent.

Item Type:	Article
Uncontrolled Keywords:	cross-sensitization; grass pollen; profilin; respiratory allergy; tomato
Subjects:	600 Technology > 01 Medical sciences > 01 Allergy 600 Technology > 08 Food technology > 23 Vegetables > 03 Tomato
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	20 Feb 2018 05:53
Last Modified:	20 Feb 2018 05:53
URI:	http://ir.cftri.res.in/id/eprint/13427

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