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Application of Probiotic Yeasts on Candida Species Associated Infection.
Lohith, K. and Anu Appaiah, K. A. and Reeta, P. Rao (2020) Application of Probiotic Yeasts on Candida Species Associated Infection. Journal of Fungi, 6. p. 189.
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Abstract
Superficial and life-threatening invasive Candida infections are a major clinical challenge in hospitalized and immuno-compromised patients. Emerging drug-resistance among Candida species is exacerbated by the limited availability of antifungals and their associated side-effects. In the current review, we discuss the application of probiotic yeasts as a potential alternative/ combination therapy against Candida infections. Preclinical studies have identified several probiotic yeasts that effectively inhibit virulence of Candida species, including Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida krusei and Candida auris. However, Saccharomyces cerevisiae var. boulardii is the only probiotic yeast commercially available. In addition, clinical studies have further confirmed the in vitro and in vivo activity of the probiotic yeasts against Candida species. Probiotics use a variety of protective mechanisms, including posing a physical barrier, the ability to aggregate pathogens and render them avirulent. Secreted metabolites such as short-chain fatty acids effectively inhibit the adhesion and morphological transition of Candida species. Overall, the probiotic yeasts could be a promising effective alternative or combination therapy for Candida infections. Additional studies would bolster the application of probiotic yeasts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Candida albicans; non-albicans Candida species; Candida auris; Saccharomyces boulardii; Saccharomyces cerevisiae; aromatic alcohols |
| Subjects: | 600 Technology > 08 Food technology > 18 Processed foods > 02 Fermented foods 600 Technology > 08 Food technology > 29 Microbiological food > 04 Yeast |
| Divisions: | Food Microbiology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 01 Jan 2021 08:34 |
| Last Modified: | 01 Jan 2021 08:34 |
| URI: | http://ir.cftri.res.in/id/eprint/14746 |
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