Anti-adipogenic and anti-obesity activity of bovine milk bioactives in 3T3L1 preadipocytes and in diet-induced obese mice.

Chaitra, Rai (2022) Anti-adipogenic and anti-obesity activity of bovine milk bioactives in 3T3L1 preadipocytes and in diet-induced obese mice. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Long-term dysregulated balance between energy intake and expenditure leading to storage of excess fat in adipose tissues is the major risk factor for obesity. The condition also characterized by uncontrolled adipogenesis and recently Dipeptidyl peptidase 4 (DPP4) is identified as one of the novel adipokine highly up regulated in obesity and adipogenesis. DPP4 exerts its effects through its various substrates including Glucagon like peptide 1(GLP1) through suppression of appetite by promoting pancreatic secretion, delaying gastric emptying, inducing satiety and modulating central nervous system signalling. Bovine milk not only consists of all the essential nutrients required for growth and development, but also provides a broad range of bioactives that are beneficial for several biological activities. In our research, we isolated and characterised bovine milk GAGs (bmGAGs) and bovine whey hydrolysates (WH) and investigated their inhibitory activity on adipogenesis via DPP4 inhibition.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	obesity, Dipeptidyl peptidase 4, Bovine milk, bovine milk GAGs, anti adipogenenic, anti-obesity effect
Subjects:	600 Technology > 01 Medical sciences > 13 Nutrition-Human 600 Technology > 08 Food technology > 27 Dairy products
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	18 May 2023 09:46
Last Modified:	18 May 2023 09:46
URI:	http://ir.cftri.res.in/id/eprint/16407

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