Rational design of antibacterial molecules by targeting Rel proteins of food borne pathogens.

Vinayak, Hegde (2021) Rational design of antibacterial molecules by targeting Rel proteins of food borne pathogens. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Bacterial resistance to existing antibiotics is a serious concern for treating infectious diseases, opportunistic pathogens, for food preservation, processing and storage. Existing antibiotics generally inhibit enzymes participating in the key bacterial processes such as cell wall and cell membrane, replication, transcription and translation. However, bacteria have rapidly evolved new mechanisms to combat these and it hence becomes indispensable to identify newer targets and search/design inhibitors against them. (p)ppGpp is one of the second messengers of bacteria that helps bacterial survival in response to various biotic and abiotic stresses. Rel protein, which synthesizes (and hydrolyzes) (p)ppGpp, is a profitable target owing to its distinct absence in humans. The present study is aimed at understanding differences, if any, among Rel from pathogenic and host bacteria.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Rel protein, natural inhibitors, antibiotic design, food borne pathogens
Subjects:	600 Technology > 01 Medical sciences > 07 Food borne disease 600 Technology > 08 Food technology > 16 Nutritive value > 03 Proteins
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	19 May 2023 09:25
Last Modified:	19 May 2023 09:25
URI:	http://ir.cftri.res.in/id/eprint/16424

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