Evaluation of acute oral toxicity of zinc phosphide in Rattus norvegicus (albino).

Krishnakumari, M. K. and Muktha Bai, K. and Majumder, S. K. (1979) Evaluation of acute oral toxicity of zinc phosphide in Rattus norvegicus (albino). Pesticides, 13 (11). pp. 33-35.

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Abstract

PESTAB. Toxicity studies were performed on female albino rats to determine the acute oral toxicity of zinc phosphide. Partially starved rats were intubated with varying concentrations of the pesticide. Doses of 21 and 28 mg/kg caused 10% mortality after an average of 18 hr. The 38 mg/kg dose produced 20% mortality. At 51.0 mg/kg 60% of the test animals died. A dose of 68 mg/kg did not increase the percent mortality above 60%, but the average time of death decreased slightly from 36 hr to 34 hr. The LD50 was calculated to be 54.0 mg/kg and the LD90 was 119.0 mg/kg. There were no changes in food intake, body weight, hematology or relative organ weights due to the pesticide. However, some histopathological lesions were observed in the kidneys of animals treated with low doses of the pesticide.

Item Type:	Article
Uncontrolled Keywords:	zinc phosphide oral toxicity albino rats
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	27 Jul 2021 09:21
Last Modified:	27 Jul 2021 09:21
URI:	http://ir.cftri.res.in/id/eprint/8623

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