Techno-economic analysis of processes for Aspergillus carbonarius polygalacturonase production.

A techno-economic analysis of submerged (SmF) and solid state fermentation (SSF) processes for Aspergillus carbonarius
polygalacturonase production was performed to make an appropriate process selection. The downstream processing involved
integrated membrane process (IMP) and alginate affinity precipitation (AAP). For a production scale of 30 kL purified
polygalacturonase concentrate per year, the total upstream cost of SmF was 14% lower than the SSF process. Downstream
processing cost by IMP was 47% lower than AAP. The SmF-IMP process required a total capital investment that was 15–24%
lower than the SmF-AAP and SSF-AAP processes. The corresponding unitary product cost was also lower by 24–36% in SmFIMP
process. Thus the SmF-IMP process proved to be very attractive from an economic point of view.