Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non‐pigmented rice bran extracts.

This study evaluated the neuroprotective efficacy of the pigmented and non‐pigmented
rice bran extract, against LPS induced neurotransmitter imbalance and oxidative
stress markers. Male wistar rats were orally supplemented with 2% ethanolic
rice bran extracts daily for two weeks. On the last day of experiment, rats were challenged
intraperitoneally (i.p) with LPS for 4 hr. LPS exposure resulted in the elevation
of malondialdehyde and nitrite levels, decreased GSH, increased antioxidant enzymes
activity and led to imbalance in neurotransmitters, norepinephrine, dopamine
and serotonin and their metabolites 3,4‐dihydroxyphenylacetic acid, homovanillic
levels and acetylcholinesterase activity. Pre‐treatment with rice bran extracts significantly
attenuated LPS induced oxidative stress by improving the antioxidant systems,
acetylcholinesterase activity and neurotransmitters imbalance with the higher potency
for pigmented bran extracts. The findings suggest the possibility of utilization
of pigmented bran extract for the prevention of neurodegenerative diseases and promote
the overall good health of the brain.
Practical application
Present study provides the current evidence for the neuroprotective efficacy of bran
extracts from pigmented and non‐pigmented rice. These findings indicate the beneficial
effects of pre‐treatment of rice bran extracts on LPS induced oxidative stress and
neurochemical imbalance by improvement in the antioxidant machinery and neurotransmitters
level. This study emphasizes the possibility of utilization of pigmented bran
extract as a food ingredient to improve the overall brain health.