Is acetylcholinesterase inhibition in Caenorhabditis elegans at sub-lethal concentrations predictive of hyperglycemic potential of anticholinesterase agents?

Apurva Kumar, R. J. and Nagaraju, Raju. and Rajini, P. S. (2020) Is acetylcholinesterase inhibition in Caenorhabditis elegans at sub-lethal concentrations predictive of hyperglycemic potential of anticholinesterase agents? Journal of Punjab Academy of Forensic Medicine and Toxicology, 20 (1). pp. 61-66.

PDF J Punjab Acad Forensic Med Toxicol 2020;20(1).pdf - Published Version Restricted to Registered users only Download (532kB)

Abstract

We explored the hypothesis that strong inhibition of acetylcholinesterase (AChE) in Caenorhabditis elegans after acute exposure (4h) to sub-lethal concentrations could serve as a model for predicting hyperglycemic potential of anti-cholinesterase toxicants. Acute exposure to sub-lethal concentrations of acephate and monocrotophos elicited significant inhibition of AChE in C. elegans. Sub-chronic exposure (90 days) to acephate (280mg/kg b.w./d) and monocrotophos (3.6mg/kg b.w./d) to male Wistar rats caused inhibition of brain AChE and increased blood glucose. Literature survey as well as previous work from our laboratory suggests that toxicants with ability to cause AChE inhibition in C. elegans also cause hyperglycemia in experimental mammalian models. This suggests that strong inhibition of C. elegans AChE after acute exposure to sub-lethal concentrations could help in predicting the ability of xenobiotics to cause disruption of glucose homeostasis in mammalian system due to AChE inhibition and cholinergic stress.

Item Type:	Article
Uncontrolled Keywords:	Acephate, Acetylcholinesterase, Caenorhabditis elegans, Glucose homeostasis, Median lethal concentration, Monocrotophos
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	01 Jan 2021 06:59
Last Modified:	01 Jan 2021 06:59
URI:	http://ir.cftri.res.in/id/eprint/14742

Actions (login required)

View Item