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Dual Mode of Action of Talaromyces purpureogenus CFRM02 Pigment to Ameliorate Alcohol Induced Liver Toxicity in Rats.
Saritha, G. Pandit and Krishna Prashanth, Ramesh Mekala and Mohankumari, H. P. and Muthukumar, S. P. and Mohan, A. Dhale (2022) Dual Mode of Action of Talaromyces purpureogenus CFRM02 Pigment to Ameliorate Alcohol Induced Liver Toxicity in Rats. Applied Biochemistry and Biotechnology, 194. pp. 4258-4265. ISSN 0273-2289
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Abstract
Talaromyces purpureogenus CFRM02 pigment exhibited antioxidant activity by scaveng�ing free radicals. The alcohol feeding leads to free radical generation causing pathophysi�ological processes of alcoholic liver disease (ALD) and alcoholic hepatitis. T. purpureo�genus CFRM02 pigment administered to rats ameliorated the ALD by scavenging ROS. The haematological analysis revealed the increased neutrophil circulation. The neutrophil infltration was observed in the hepatocytes of the rats fed with pigment (600 mg/kg body weight). The increase in the number of neutrophils helps in liver regeneration caused by alcoholic hepatitis. The dual mechanism of action of pigment, antioxidant and liver regen�eration through neutrophil production is attributed to alleviate the ALD. These results sug�gested that T. purpureogenus CFRM02 pigment represents the protective and therapeutic strategy against ALD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Talaromyces purpureogenus · Pigment · Alcohol-toxicity · Hepatoprotective · Free radical · Neutrophils |
| Subjects: | 600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 05 Chemical engineering > 04 Fermentation Technology 600 Technology > 08 Food technology > 21 Cereals > 01 Rice |
| Divisions: | Dept. of Biochemistry Food Microbiology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 24 Jan 2023 09:39 |
| Last Modified: | 24 Jan 2023 09:39 |
| URI: | http://ir.cftri.res.in/id/eprint/15852 |
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