Modulation of hyperglycemia induced oxidative stress-mediated retinal angiogenesis with astaxanthin in vitro and in vivo.

Janani, R. (2021) Modulation of hyperglycemia induced oxidative stress-mediated retinal angiogenesis with astaxanthin in vitro and in vivo. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Diabetic retinopathy (DR), a debilitating microvascular complication, is the major cause of vision loss in the diabetic population. Vascular endothelial growth factor (VEGF) plays a detrimental role in the pathogenesis of DR. There were compelling pieces of evidence for the involvement of hypoxia and endoplasmic reticulum stress in the upregulation of VEGF under diabetic conditions. Thus, targeting VEGF and its associated pathways is an effective strategy to control DR. Astaxanthin has been reported to possess beneficial effects in the treatment of several ocular diseases. Hence, we aimed to understand the underlying mechanism of astaxanthin in protecting the retinal cells in vitro (ARPE-19 cells) and in vivo (streptozotocin�induced diabetic rats). Initially, we found that high glucose/ hypoxia-mediated generation of ROS and lipid peroxidation in ARPE-19 cells were significantly declined upon astaxanthin treatment in a dose-dependent manner. Similarly, the nitric oxide, protein carbonyl, and lipid peroxide levels were significantly increased in diabetic group compared to control and astaxanthin treated groups.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	astaxanthin, Diabetic retinopathy, Vascular endothelial growth factor, retinal dysfunction
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	18 May 2023 11:10
Last Modified:	18 May 2023 11:10
URI:	http://ir.cftri.res.in/id/eprint/16412

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