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Characterization of dehydromonacolin-MV2 from Monascus purpureus mutant.
Dhale, M. A. and Divakar, S. and Umesh Kumar, S. and Vijayalakshmi, G. (2007) Characterization of dehydromonacolin-MV2 from Monascus purpureus mutant. Journal of applied microbiology, 103 (6). pp. 2168-73. ISSN 1364-5072
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Abstract
AIM: Characterization of dehydromonacolin-MV2, a bioactive metabolite isolated from Monascus purpureus mutant (CFR 410-11). METHODS AND RESULTS: Chloroform extract of rice, fermented with a hyperpigment-producing mutant of M. purpureus (CFR 410-11) was found to contain metabolites that inhibited the growth of Bacillus, Pseudomonas and Streptococcus in agar gel diffusion assays. The extract inhibited lipid peroxidation and scavenged 2,2-diphenyl-1-pycrylhydrazyl and hydroxyl radicals. The active compound purified by silica gel column chromatography was characterized by NMR. The carbon, proton and 2D HSQCT assignments identified dehydromonacolin-MV2 as the bioactive metabolite. CONCLUSIONS: Dehydromonacolin-MV2 apparently originated in the mutant by hydroxylation and oxidation of monacolin-J, an intermediate of monacolin biosynthetic pathway. SIGNIFICANCE AND IMPACT OF THE STUDY: Identification of the production of dehydromonacolin-MV2 by M. purpureus mutant (CFR 410-11) is new to literature. Bioactive properties of the compound suggested its pharmaceutical applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antibacterial, dehydromonacolin-MV2, DPPH, hydroxyl radical, lipid peroxidation, M. purpureus. |
| Subjects: | 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi 600 Technology > 08 Food technology > 32 Antioxidants |
| Divisions: | Fermentation Technology and Bioengineering Food Microbiology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 09 Aug 2008 07:05 |
| Last Modified: | 30 May 2012 11:09 |
| URI: | http://ir.cftri.res.in/id/eprint/1817 |
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