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Hydroxypropyl methylcellulose stabilized clove oil nanoemulsified orodispersible films: Study of physicochemical properties, release profile, mucosal permeation, and anti-bacterial activity.
Aswathy, K. V. and Beulah, K.C. and Nalina, M. and Sunil Ambedkar, D. and Leela Sairam, A. and Poornima Priyadarshini, C. G. and Arunkumar, P. and Pooja, J. Rao (2024) Hydroxypropyl methylcellulose stabilized clove oil nanoemulsified orodispersible films: Study of physicochemical properties, release profile, mucosal permeation, and anti-bacterial activity. International Journal of Biological Macromolecules, 283. p. 137577. ISSN 0141-8130
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Abstract
Hydroxypropyl methylcellulose (HPMC)-based nanoemulsions for quick dissolving orodispersible (OD) films were prepared to encapsulate clove oil (CO) to harness its anti-bacterial properties. The influence of additives maltodextrin, pectin, and glycerol on the OD films was studied. The nanoemulsion particle size varied from 135 nm to 195 nm. A decrease in tensile strength and, an increase in elongation at break and opacity were observed in OD films compared to neat HPMC film. The AFM images showed an increase in HPMC films’ average roughness from 6.95 to 90 nm after adding CO and additives. The additives controlled CO in-vitro release from HPMC following the Higuchi model. The ex-vivo permeation through porcine mucosal membrane was 9–33 % while the permeation coefficient and flux were 0.282–0.879 cm s
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Orodispersible film Biocompatible polymer Clove oil Mucosal permeation Kinetics study models Antibacterial activity |
| Subjects: | 600 Technology > 08 Food technology > 06 Preservation and Storage > 06 Packaging 600 Technology > 09 Industrial oils, fats, waxes, gases > 03 Essential oils |
| Divisions: | Food Packaging Technology Molecular Nutrition Plantation Products Spices and Flavour Technology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 18 Dec 2024 08:44 |
| Last Modified: | 18 Dec 2024 08:44 |
| URI: | http://ir.cftri.res.in/id/eprint/18855 |
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