Inhibitory effect of Tridax procumbens against human skin pathogens

Policegoudra, R. S. and Chattopadhyay, P. and Aradhya, S. M. and Shivaswamy, R. and Singh, L. and Veer, V. (2014) Inhibitory effect of Tridax procumbens against human skin pathogens. Journal of herbal medicine, 4. pp. 83-88.

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Abstract

Tridax procumbens is a common herb with significant medicinal properties traditionally used in the treatment of many skin diseases. The methanol extract of T. procumbens exhibited high antifungal activity against clinically important human skin pathogens such as Microsporum fulvum, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichosporon beigelii and Candida albicans with low MIC values. The fractionation of a methanol extract with dichloromethane yielded an oily viscous fluid with antifungal activity which was sep- arated and characterized. The GC–MS analysis revealed the presence of 26 compounds. The major constituents were characterized as 9,12-octadecadienoic acid ethyl ester (18.04%), 5␣-cholestane (12.42%), hexadecanoic acid ethyl ester (4.86%) and 9-octadecenoic acid ethyl ester (4.72%). This study demonstrated the efficacy of this herb against clinically important dermatophytes and also justified its traditional use.

Item Type:	Article
Uncontrolled Keywords:	Tridax procumbens, Dermatophytes, Antifungal activity, GCMS, MIC, Fatty acids
Subjects:	500 Natural Sciences and Mathematics > 10 Plants 600 Technology > 01 Medical sciences > 01 Allergy
Divisions:	Fruit and Vegetable Technology
Depositing User:	Somashekar K S
Date Deposited:	11 Mar 2025 08:51
Last Modified:	11 Mar 2025 08:51
URI:	http://ir.cftri.res.in/id/eprint/19273

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