Vishwanath, P. and Basappa, S. C. and Sreenivasamurthy, V. (1986) Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium. Folia Microbiologica, 31 (4). pp. 272-276.
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Abstract
Thymine and cytosine as well as the intermediates in pyrimidine biosynthetm
pathway dihydroorotic acid, erotic acid, earbamyl aspartate and 5'-uridine monophosphato
counteracted the toxic effect of aflatoxin in Bacillus megaterium. Folio acid and aminopterin
counteracted the effect even better. The synergistic effect of thymine or 5'-uridlne monophosphate
and relic acid, was synergistic. 2-14C-Thymine, 6-1aC-orotic acid and 14C-formate but not 2-14Curacil,
were incorporated into DNA more in the presence of aflatoxin. These findings indicated
that aflatoxin inhibited the pyrimidine base synthesis which could be overcome to a great extent
by the addition of thymine and folic acid to aflatoxin-treated cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aflatoxin, Bacillus megaterium, Thymine, toxicity |
| Subjects: | 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi 600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 08 Food technology > 10 Food Microorganisms |
| Divisions: | Food Microbiology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 16 Mar 2018 09:46 |
| Last Modified: | 16 Mar 2018 09:46 |
| URI: | http://ir.cftri.res.in/id/eprint/2694 |
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