Effect Of Butyric Acid Supplementation On Serum And Renal Antioxidant Enzyme Activities In Streptozotocin-Induced Diabetic Rats

Reactive oxygen metabolites, which are constant products of normal
aerobic cell metabolism, play a key role in worsening the pathophysiological
complications of diabetes. The present investigation was aimed at understanding
the effect of butyric acid supplementation along with wheatbran and guar
gum on serum and renal antioxidant enzyme activities and lipid peroxidation
in streptozotocin (STZ)-induced diabetic rats. Activities of superoxide dismutase,
catalase, glutathione peroxidase were evaluated in serum and kidney of
control and experimental rats. Results clearly showed that the altered activity
of the enzymes during diabetes was significantly ameliorated by butyric acid
(500 mg/kg body weight/day) supplementation compared with other experimental
groups. Further, the increased lipid peroxidation in serum and kidney
of diabetic rats was also significantly reduced in butyric acid-supplemented
diabetic rats. The study led us to conclude that butyric acid exert antioxidant
property, thereby minimizing oxidative stress induced diabetes and its related
complications.