Effect of norbormide on blood glucose levels in albino rats.

Norbormide at a toxic dose level (1.2 m.gfiOO g body wt), irrespective of the mOde of administration,
causes a signiftcant rise in blood glucose levels with a concomitant fall in hepatic
glycogen contents of albino rats. Two strains of mice ar.., however, devoid of this effect. Glycogen
contents of skeletal muscle and glutathione contents of liver are also decreased. Insulin
is able to reverse the hyperglycemic effect, but it cannot protect the rats against other toxic
manifestations and subsequent death.