Antioxidant potentials of flaxseed by in vivo model.

Rajesha, J. and Chidambara Murthy, K. N. and Karun Kumar, M. and Basavaraj, Madhusudhan and Ravishankar, G. A. (2006) Antioxidant potentials of flaxseed by in vivo model. Journal of Agricultural and Food Chemistry, 54 (11). 3794-3799 ; 48 ref..

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Abstract

Antioxidative activity of flax seeds, measured by feeding weanling albino rats with 5.0 and 10.0% flax seed (constituting approx. 0.75 and 1.5 g/kg) for 14 days followed by challenge with 2.0 g/kg body wt. of the toxin carbon tetrachloride (CCl4), was determined. Activity was assessed by measuring the activities of hepatic marker enzymes (catalase, superoxide dismutase (SOD), peroxidase), and comparing the measurements with those from an untreated (control) group and from a group receiving toxin only. CCl4 treatment at 2.0 g/kg body wt. decreased the activities of catalase, SOD and peroxidase by 35.6, 47.76 and 53.0%, respectively, compared to the control group, and the lipid peroxidation value increased approx. 1.2x compared to that of the group treated with toxin only. Feeding rats with 5.0% flax seed followed by CCl4 treatment restored catalase, SOD and peroxidase acitivites by 39.7, 181.42 and 123.7%, respectively, compared to the control. Feeding rats with 10.0% flax seed restored catalase, SOD and peroxidase activities by 95.02, 182.31 and 136.0%, respectively. In the case of the group treated with toxin without flax seed, SOD and catalase activities decreased 91.4 and 55.33%, respectively, compared to the control group. Results clearly indicated the beneficial effect of flax seed components as an antioxidant, as shown by restoration of hepatic enzyme activities, which varied from normal to 1 due to toxicity induced by CCl4. It is therefore suggested that flax seed may be suitable for use in nutraceuticals and as a food ingredient.

Item Type:	Article
Uncontrolled Keywords:	OILSEEDS-; OXIDATION-; OXIDOREDUCTASES-; PEROXIDASES-; ANIMAL-MODELS; ANTIOXIDATIVE-ACTIVITY; CATALASES-; FLAX-SEEDS; SUPEROXIDE-DISMUTASES
Subjects:	600 Technology > 08 Food technology > 22 Legumes-Pulses 600 Technology > 08 Food technology > 16 Nutritive value > 10 Antioxidant Property
Divisions:	Plant Cell Biotechnology
Depositing User:	Users 16 not found.
Date Deposited:	28 Jun 2011 11:17
Last Modified:	23 May 2012 06:22
URI:	http://ir.cftri.res.in/id/eprint/7505

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