Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023

Salimath, P. V. and Jürgen, Weckesser and Wolfgang, Strittmatter (1983) Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023. European Journal of Biochemistry, 136 (1). pp. 195-200.

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Abstract

The lipid A isolated from Rhodopseudomonas sphaeroides ATCC 17023 has been investigated. A sequence of analyses indicated β-D-glucosaminyl-1,6-D-glucosamine as the sugar backbone carrying phosphate groups at C-1 of the reducing glucosamine and C-4 of the non-reducing glucosamine. Both 3-(7-tetradecenoyl)oxytetradecanoic and 3-oxotetradecanoic acid are linked to the NH2 groups. Two residues of 3-hydroxydecanoic acid are linked to hydroxy groups at C-3 of both reducing and non-reducing glucosamine, and the hydroxy group of 3-hydroxydecanoic acid is free. In free lipid A, the hydroxy group at C-4 of the reducing glucosamine and at C-6 of the non-reducing glucosamine are unsubstituted. The latter probably arises from a 3-deoxy-D-manno-octulosonate linkage. The structural similarities and dissimilarities existing between lipid A of R. sphaeroides, which is non-toxic, and lipid A types such as those from Salmonella, which are toxic, are discussed.

Item Type:	Article
Uncontrolled Keywords:	lipid A, Rhodopseudomonas sphaeroides
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 02 Bacteriology 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	26 Sep 2010 09:10
Last Modified:	28 Dec 2011 10:00
URI:	http://ir.cftri.res.in/id/eprint/7789

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