Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats

Nandita, Singh and Vasudeva, Kamath and Narasimhamurthy, K. and Rajini, P.S. (2008) Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats. Environmental Toxicology and Pharmacology, 26. pp. 241-246.

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Abstract

Our earlier studies have shown that extracts derived from potato peel (PPE) are rich in polyphenols and possess strong antioxidant activity both in vitro and in vivo. The objective of the present study was to investigate its potential to offer protection against acute liver injury in rats. Rats pretreated with PPE (oral, 100 mg/kg b.w./day for 7 days) were administered a single oral dose carbon tetrachloride (CCl4, 3 ml/kg b.w., 1:1 in groundnut oil) and sacrificed 8 hof post-treatment. Hepaticdamagewas assessed byemploying biochemical parameters (transaminase enzyme levels in plasma and liver [AST—aspartate transaminase; ALT—alanine transaminase, LDH—lactate dehydrogenase]). Further, markers of hepatic oxidative damage were measured in terms of malondialdehyde (MDA), enzymic antioxidants (CAT, SOT, GST, GPX) and GSH (reduced glutathione) levels. In addition, the CCl4-induced pathological changes in liver were evaluated by histopathological studies. Our results demonstrated that pretreatment of rats with PPE significantly prevented the increased activities of AST and ALT in serum, prevented the elevation of hepatic MDA formation aswell as protected the liver from GSH depletion. PPE pretreatment also restored CCl4-induced altered antioxidant enzyme activities to control levels. The protective effect of PPE was further evident through the decreased histological alterations in liver. Our findings provide evidences to demonstrate that PPE pretreatment significantly offsets CCl4-induced liver injury in rats, which may be attributable to its strong antioxidant propensity.

Item Type:	Article
Uncontrolled Keywords:	Potato peel Free radical Carbon tetrachloride (CCl4) Liver injury Rat Antioxidant activity
Subjects:	600 Technology > 08 Food technology > 23 Vegetables > 02 Potato 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry 600 Technology > 08 Food technology > 32 Antioxidants
Divisions:	Food Protectants and Infestation Control Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 Jun 2009 06:19
Last Modified:	28 Dec 2011 10:10
URI:	http://ir.cftri.res.in/id/eprint/9089

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