Effect of mango (Mangifera indica L.) peel on hyperglycemia and changes in crystallin during cataract formation in diabetic rats.

Diabetes mellitus, commonly referred to as diabetes, is a metabolic disorder
and it is characterized by hyperglycemia. Diabetes results from defects in insulin
secretion, or insulin action or both. Several million people are affected with diabetes
mellitus and the number of people with diabetes is projected to rise. Prolonged
exposure to hyperglycemia is associated with long-term damage of dysfunction and
failure of different organ, especially the eyes, kidneys, nerves, heart and blood vessels
and leads to pathogenesis of diabetic complications. Hyperglycemia may increase
oxidative stress via alterations of key metabolic pathways such as polyol pathway flux
and increased AGEs formation. Patients suffering from diabetes are at an increased
risk of developing cataract at an earlier age than people without diabetes.