Identification of bioactives from Carissa spinarum fruits and their anti-quorum sensing activity on food borne pathogens.

Maria Sheeba, Nazareth (2021) Identification of bioactives from Carissa spinarum fruits and their anti-quorum sensing activity on food borne pathogens. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Quorum sensing (QS) regulates several traits like virulence, biofilm formation, motility, conjugation at a cell density population through a signal molecule known as acyl-homoserine lactone (AHL) in Gram-negative bacteria. QS traits like biofilm and motility play a major role in pathogens related to human infection and food spoilage. Plant secondary metabolites or bioactive compounds have been shown as safe inhibitors of QS in food borne pathogens thus controlling spoilage and infections as there is no selective pressure that makes microbes less resistant. Fruits are one of the richest sources of bioactive compounds. Carissa spinarum is an underutilized plant found widely in drylands of the Western Ghats region of India which bears delicious berry-sized fruits. It has been consumed by tribes and local people and used in the form of pickles, salads, jam and jellies and is used to cure gastrointestinal infection indicating its antibacterial activity, however, had no valid scientific evidence. Though the underutilized fruits of C. spinarum have bioactive compounds, the changes in the nutritional and nutraceutical potential of C. spinarum fruits during ripening had not been exploited. Our study revealed fruits showed a good amount of carbohydrate, protein, and lipid and was observed during ripening the phenolics and flavonoids content increased and ripe fruits had a good amount of anthocyanin as those of commercially available strawberries

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Quorum sensing, bioactive compounds, Carissa spinarum, food formulations, molecular docking analysis
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 18 Phytochemistry 600 Technology > 01 Medical sciences > 07 Food borne disease 600 Technology > 08 Food technology > 24 Fruits
Divisions:	Plant Cell Biotechnology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	19 May 2023 05:34
Last Modified:	19 May 2023 05:34
URI:	http://ir.cftri.res.in/id/eprint/16416

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